Anti-Mouse CD122 (IL-2Rβ) - APC

CD122 is a 70-75 kD IL-2 receptor β chain that is a type I membrane protein.

CD122 is involved in T cell-mediated immune responses and its activation increases proliferation of CD8+ effector T cells.

It exists in three forms with varying degrees of binding affinity with IL-2.

The low affinity form is a monomer of the α subunit and has no involvement in signal transduction.

The intermediate affinity form is a γ/β heterodimer and the high affinity form is an α/β/γ heterotrimer.

The intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

This protein also interacts with the IL-15 receptor.