Anti-Mouse CD178 (FasL) - Biotin

FasL antibody, clone AFS98, recognizes Fas ligand (FasL), also known as CD178, Apo-1 ligand, and CD95 ligand.

FasL is a 40 kDa type II integral membrane protein that belongs to the tumor necrosis factor (TNF) superfamily.

FasL is expressed by activated T cells and natural killer (NK cells)1-3.

Binding of FasL to its receptor Fas (CD95, APO-1) induces apoptotic cell death in Fas-expressing target cells, contributing to anti-viral immunity.

FasL also contributes to peripheral tolerance and the downregulation of immune responses through activation-induced autocrine and paracrine T cell death4.

FasL is also found in the anterior chamber of the eye and on Sertoli cells in the testis, and is implicated in immune-privilege at these sites5,6.

FasL also contributes to CD8 proliferation and neutrophil recruitment7,8.

Soluble FasL (26 kDa) can be released following cleavage by metalloproteinases and block FasL-mediated signaling9.

Fas/FasL-signaling is involved in the development of many human diseases, including autoimmunity and cancer10.

Many human tumors over-express FasL, resulting in tumor infiltrating lymphocyte (TIL) apoptosis and immune evasion, which is associated with poor prognosis11-14.